Publications
Published Work
Duran Ramirez, J. M., Gomez, J., Hanson, B. M., Isa, T., Myckatyn, T. M., & Walker, J. N. (2022). Staphylococcus aureus Breast Implant Infection Isolates Display Recalcitrance to Antibiotic Pocket Irrigants. Microbiology Spectrum, e02884-22.
Vuong, L. N., Dorsey, D., Obernuefemann, C., Pinkner, J., Walker, J. N., Hultgren, S., & Myckatyn, T. M. (2022). Characterization of host-pathogen-device interactions in Pseudomonas aeruginosa infection of breast implants. Plastic and reconstructive surgery, 10.1097/PRS.0000000000009315. Advance online publication. https://doi.org/10.1097/PRS.0000000000009315
Duran Ramirez, J. M., Gomez, J., Obernuefemann, C., Gualberto, N. C., & Walker, J. N. (2022). Semi-Quantitative Assay to Measure Urease Activity by Urinary Catheter-Associated Uropathogens. Frontiers in cellular and infection microbiology, 12, 859093. https://doi.org/10.3389/fcimb.2022.859093
Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM. Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis. Aesthet Surg J. 2020 Feb 17;40(3):281-295. doi: 10.1093/asj/sjz099. PubMed PMID: 30953053.
Walker JN, Hanson BM, Pinkner CL, Simar SR, Pinkner JS, Parikh R, Clemens MW, Hultgren SJ, Myckatyn TM. Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma. Sci Rep. 2019 Jul 17;9(1):10393. doi: 10.1038/s41598-019-46535-8. PubMed PMID: 31316085; PubMed Central PMCID: PMC6637124.
Walker JN, Poppler L, Pinkner CL, Hultgren SJ, Myckatyn T. Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model. Aesthet Surg J. 2019 Jul 1;. doi: 10.1093/asj/sjz190. [Epub ahead of print] PubMed PMID: 31259380.
Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM. The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants. Plast Reconstr Surg Glob Open. 2019 Feb;7(2):e2037. doi: 10.1097/GOX.0000000000002037. eCollection 2019 Feb. PubMed PMID: 30881821; PubMed Central PMCID: PMC6416121.
Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL 4th, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ. Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8721-E8730. doi: 10.1073/pnas.1707572114. Epub 2017 Sep 25. PubMed PMID: 28973850; PubMed Central PMCID: PMC5642702.
Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG. Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections. mBio. 2016 Oct 25;7(5). doi: 10.1128/mBio.01653-16. PubMed PMID: 27795399; PubMed Central PMCID: PMC5080383.
Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A. Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures. J Urol. 2016 Aug;196(2):416-421. doi: 10.1016/j.juro.2016.01.100. Epub 2016 Jan 28. PubMed PMID: 26827873; PubMed Central PMCID: PMC4965327.
Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015 May;13(5):269-84. doi: 10.1038/nrmicro3432. Epub 2015 Apr 8. Review. PubMed PMID: 25853778; PubMed Central PMCID: PMC4457377.
Walker JN, Crosby HA, Spaulding AR, Salgado-Pabón W, Malone CL, Rosenthal CB, Schlievert PM, Boyd JM, Horswill AR. The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. PLoS Pathog. 2013;9(12):e1003819. doi: 10.1371/journal.ppat.1003819. Epub 2013 Dec 19. PubMed PMID: 24367264; PubMed Central PMCID: PMC3868527.
Walker JN, Horswill AR. A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma. Front Cell Infect Microbiol. 2012;2:39. doi: 10.3389/fcimb.2012.00039. eCollection 2012. PubMed PMID: 22919630; PubMed Central PMCID: PMC3417647.
Lin LY, Tiemann KM, Li Y, Pinkner JS, Walker JN, Hultgren SJ, Hunstad DA, Wooley KL. Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization. J Am Chem Soc. 2012 Mar 7;134(9):3938-41. doi: 10.1021/ja2091917. Epub 2012 Feb 23. PubMed PMID: 22360307; PubMed Central PMCID: PMC3325780.
Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ. Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22439-44. doi: 10.1073/pnas.0902179106. Epub 2009 Dec 16. PubMed PMID: 20018753; PubMed Central PMCID: PMC2794649.
Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ. Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nat Chem Biol. 2009 Dec;5(12):913-9. doi: 10.1038/nchembio.242. Epub 2009 Oct 25. PubMed PMID: 19915538; PubMed Central PMCID: PMC2838449.
Mysorekar IU, Isaacson-Schmid M, Walker JN, Mills JC, Hultgren SJ. Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe. 2009 May 8;5(5):463-75. doi: 10.1016/j.chom.2009.04.005. PubMed PMID: 19454350; PubMed Central PMCID: PMC2696285.
Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ. Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli. PLoS Pathog. 2009 Feb;5(2):e1000305. doi: 10.1371/journal.ppat.1000305. Epub 2009 Feb 20. PubMed PMID: 19229321; PubMed Central PMCID: PMC2637984.
Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ. Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun. 2008 Jul;76(7):3337-45. doi: 10.1128/IAI.00090-08. Epub 2008 Apr 14. PubMed PMID: 18411285; PubMed Central PMCID: PMC2446714.
Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ. Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun. 2008 Jul;76(7):3346-56. doi: 10.1128/IAI.00340-08. Epub 2008 May 12. PubMed PMID: 18474655; PubMed Central PMCID: PMC2446687.
Hannan TJ, Mysorekar IU, Chen SL, Walker JN, Jones JM, Pinkner JS, Hultgren SJ, Seed PC. LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Mol Microbiol. 2008 Jan;67(1):116-28. doi: 10.1111/j.1365-2958.2007.06025.x. Epub 2007 Nov 25. PubMed PMID: 18036139; PubMed Central PMCID: PMC3675907.